Symbol
Name
ID

Vhl
von Hippel-Lindau tumor suppressor
MGI:103223

Phenotype annotations related to renal/urinary system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Proteinuria	Elevated urinary norepinephrine level	Renal artery stenosis	Multiple renal cysts	Renal cell carcinoma
Disease(s) Associated with VHL	Proteinuria	Elevated urinary norepinephrine level	Renal artery stenosis	Multiple renal cysts	Renal cell carcinoma
pheochromocytoma
renal cell carcinoma
von Hippel-Lindau disease

Mouse Phenotypes

renal/urinary system phenotype

dilated glomerular capillary

abnormal kidney vasculature morphology

increased mesangial cell number

decreased renal tubule apoptosis

kidney cyst

kidney cortex cyst

albuminuria

decreased susceptibility to kidney reperfusion injury

kidney inflammation

abnormal kidney morphology

dilated kidney collecting duct

podocyte foot process effacement

decreased podocyte number

abnormal renal glomerulus basement membrane morphology

increased renal glomerulus basement membrane thickness

expanded mesangial matrix

glomerular crescent

renal glomerulus fibrosis

renal interstitial fibrosis

hydronephrosis

dilated renal tubule

renal cast

kidney failure

Availability

Mouse Genotype

Vhl^tm1.1Wkr/Vhl⁺

Hprt1^{tm1(Pck1-cre)Vhh}/Y
Vhl^tm1Jae/Vhl^tm1Jae (conditional)

Vhl^tm1Jae/Vhl^tm1Jae
Tg(Cdh16-cre)91Igr/0 (conditional)

Vhl^tm1Jae/Vhl^tm1Jae
Tg(NPHS2-cre)295Lbh/? (conditional)

Vhl^tm1Lss/Vhl^tm1.1Lss
Tg(CAG-cre/Esr1*)1Lbe/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23